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41例热毒宁注射液不良反应分析
Analysis of 41 Cases of Adverse Drug Reaction Induced by Reduning Injection
  
DOI:
中文关键词:  热毒宁注射液  药品不良反应  变态反应
英文关键词:Reduning injection  Adverse drug reaction  Allergic reactions
基金项目:2013年度惠州市技术研究与开发资金计划项目 (编号:2013G02)
作者单位
詹云丽 惠州市药品不良反应监测中心(广东惠州 516003) 
杨小瑶 惠州市药品不良反应监测中心 
罗东丽 惠州市药品不良反应监测中心 
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中文摘要:
      摘 要 目的:分析41例热毒宁注射液不良反应(ADR)病例,探讨ADR发生的相关因素方法:提取惠州市2013年1月~2014年9月药品不良反应网络管理平台中41例热毒宁注射液ADR病例报告,分别统计患者性别、年龄、原患疾病,ADR累及的系统 器官及临床表现等并作分析。结果:41份ADR报告中,不良反应集中在儿童组,以变态反应居多,主要累及皮肤及其附件损害(53.8%);78.1%的ADR发生在用药30 min内;82.9%的关联性评价结果为很可能;均为单独用药后发生的ADR。结论:医务人员应该重视热毒宁注射液的不良反应,加强临床使用过程的主动监测,分析ADR的发生特点,尽量减少或避免ADR的发生,确保临床用药安全。
英文摘要:
      ABSTRACT Objective:To analyze 41 ADR cases of the Reduning Injection to explore the causes of adverse reactions, provide a reference for clinical rational use of drugs. Methods:On the basis of adverse drug reaction network management platform in Huizhou, 41 cases of ADR reports caused by Reduning from January 2013 to September 2014 were analyzed in terms of the age, gender, system organs involved, clinical manifestation and so on. Results:Among 41 ADR reports, highest rate of ADR occurred in children patients; Allergic reactions were commonand the ADR mainly involved skin and its appendages damage(53.8%);78.1% ADR were happened in 30 minutes; The evaluation result for the correlation of 82.9% was likely; All of these cases were single medication using. Conclusion:Doctors and pharmacists should pay more attention to the ADR of Reduning injection, strengthen to the monitor of drug use, and analyze its characteristics, so as to reduce or avoid the occurrence of ADR, ensure clinical safety.
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