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| 结直肠癌遗传流行病与药物基因组学研究概述 |
| Colorectal Cancer：Genetic Epidemiology and Pharmacogenomics |
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| DOI： |
| 中文关键词: 结直肠癌 遗传流行病学 药物基因组学 氟尿嘧啶 |
| 英文关键词:Colorectal Neoplasms Genetic Epidemiology Pharmacogenetics Fluorouracil |
| 基金项目: |
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| 中文摘要: |
| 摘 要 结直肠癌的发病率与死亡率均位居恶性肿瘤前列，全基因组关联研究开展以来发现了许多与结直肠癌发病有关的位点，基因-基因与基因-环境相互作用研究也有助于阐明结直肠癌的发病机制和影响因素，同时，化疗药物和分子靶向治疗药物的药物基因组学研究也发现药物代谢途径相关的基因突变在药物的疗效和不良反应中起到了关键作用。 |
| 英文摘要: |
| ABSTRACT Colorectal cancer ranks among the most important cause of the malignant tumor morbidity and mortality for mankind. The genome-wide association study（GWAS）helped us learn the relationship between gene locus mutations and colorectal cancer; besides, the study of gene-gene and gene-environment interactions helped to elucidate the pathogenesis and influencing factors of colorectal cancer. Meanwhile, the research of pharmacogenomics of chemotherapy drugs and molecular targeted drug played a key role in the study of efficacy and adverse reaction that was related to drug metabolism. |
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