| ABSTRACT Testosterone replacement therapy has been shown to increase serum testosterone to physiology levels, improve the life quality of the patients with testosterone deficiency, however, it is real that the long term testosterone replacement therapy. As for cardiovascular patients, it should be prudent to be cured by testosterone replacement therapy. Testosterone replacement therapy could increase prostate specific antigen, but it didn’t add the morbidity of prostate cancer. Small sample size has proved that testosterone replacement therapy improved lower urinary tract symptoms, but therapeutic mechanism isn’t clear. Owing to lack of long term randomize trial to observe two adverse effects of testosterone replacement therapy Erythrocytosis, obstructive sleep apnea, clinicians are advised to check hematocrit and focus patients’ sleep. |
