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| 4种血管紧张素Ⅱ受体拮抗药治疗高血压合并高尿酸血症患者的疗效和经济学比较 |
| Efficacy and Pharmacoeconic Comparison of Four Kinds of Angiotensin Ⅱ Receptor Blockers for Patients with Hypertension Companied by Hyperuricemia |
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| DOI： |
| 中文关键词: 厄贝沙坦；缬沙坦；替米沙坦；氯沙坦钾；高血压；高尿酸血症；疗效 药物经济学 |
| 英文关键词:Irbesartan Valsartan Telmisartan Losartan potassium Hypertension Hyperuricemia Efficacy Pharmacoeconomic |
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| 中文摘要: |
| 摘 要 目的:比较血管紧张素Ⅱ受体拮抗药（ARB）在我院高血压合并高尿酸血症患者中应用的疗效及经济学差异。方法：回顾性分析2014年1~10月在我院确诊高血压合并高尿酸血症的住院患者283例，根据使用ARB品种分为厄贝沙坦组(68例)、缬沙坦组(72例)、替米沙坦组(70例)、氯沙坦钾组(73例)，比较4组治疗前后血压、血尿酸的变化情况，药品费用及不良反应发生率。结果：各组治疗后的收缩压和舒张压较治疗前明显下降(P<0.05)；各组治疗后的血尿酸水平与治疗前差异有统计学意义(P<0.05)，氯沙坦钾组治疗后的血尿酸水平明显低于其他组(P<0.01)。4组患者使用药物费用差异有统计学意义(P<0.05)。结论：4种ARB类药物均能有效治疗高血压，氯沙坦钾除了有效控制血压外，降低血尿酸水平优于其他ARB类药物。 |
| 英文摘要: |
| ABSTRACT Objective: To compare efficacy of angiotensin Ⅱ receptor blockers(ARB) for patients with hypertension companied by hyperuricemia. Methods:Using retrospectively analysis, 283 cases of patients with hypertension companied by hyperuricemia in our hospital from January to October of 2014 were assigned to irbesartan group (n=68), valsartan group (n=72), telmisartan group (n=70) and losartan potassium group (n=73) according to the ARB kinds. The blood pressure，uric acid and incidence of adverse drug reactions of each group were compared.Results:There were significantly decreased of systolic and diastolic blood pressure after treatment (P<0.05). The blood uric acid level had significant difference after treatment (P<0.05). Blood uric acid levels of losartan potassium group was obviously lower than others after treatment(P<0.01). There were significant differences in drug costs between the four groups(P<0.05). Conclusion:The four kinds of ARB could effectively cure high blood pressure, except effective control of blood pressure, losartan potassium could better lower blood uric acid level than other ARB. |
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