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| 双歧三联活菌胶囊对溃疡性结肠炎患者血清超敏C反应蛋白及降钙素原水平的影响及疗效观察 |
| Influence and Curative Effect Observation of Bifid Triple Viable Capsules on Serum High Sensitive C Reactive Protein and Procalcitonin Levels of Patients with Ulcerative Colitis |
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| DOI： |
| 中文关键词: 溃疡性结肠炎 双歧三联活菌胶囊 超敏 C 反应蛋白 降钙素原 |
| 英文关键词:Ulcerative colitis Bifid triple viable capsules High sensitive C reactive protein Procalcitonin |
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| 中文摘要: |
| 摘 要 目的:探讨双歧三联活菌胶囊对溃疡性结肠炎(UC)患者血清超敏 C 反应蛋白(hs-CRP)及降钙素原(PCT)水平的影响及疗效观察。方法：活动期UC门诊患者96例随机分为观察组和对照组各48例。对照组患者予调整饮食及5-氨基水杨酸1.0 g，po, tid；观察组在此基础上加用双歧三联活菌胶囊630 mg，potid。均连用10周。观察两组治疗前后血清hs-CRP和PCT水平变化，比较临床疗效及药品不良反应。结果：治疗10周后，两组患者血清hs-CRP和PCT水平均较治疗前明显下降(P<0.05和P<0.01)，且观察组水平明显低于对照组(P<0.05)。观察组临床总有效率明显优于对照组(P<0.05)，两组药品不良反应例数比较，差异无统计学意义(P>0.05)。结论：双歧三联活菌胶囊治疗UC的临床疗效较显著，安全性好，与降低血清hs-CRP和PCT水平，抑制肠黏膜炎症反应过程密切相关。 |
| 英文摘要: |
| ABSTRACT Objective:To discuss the influence and curative effect observation of bifid triple viable capsules on serum high sensitive C reactive protein (hs-CRP) and procalcitonin (PCT) levels of patients with ulcerative colitis (UC).Methods:96 cases of patients with UC in actively period were divided into observation group (48 cases) and control group (48 cases) at random. The patients in two groups were given diet adjustment and oral 5 aminosalicylic acid 1.0g, three times a day. The patients in observation group were additionally given bifid triple viable capsules 630mg per time, three times a day for 10 weeks. The changes of serum hs-CRP and PCT levels of patients in two groups before and 10 weeks after medical treatment were observed, and the clinical curative effect and adverse drug reaction were compared as well. Results:After 10 weeks’ medical treatment, serum hs-CRP and PCT levels of patients in two groups obviously declined than before (P<0.05 and P＜0.01), and the declining rate of patients in observation group was much higher than that in control group (P<0.05). Meanwhile, total clinical efficiency of patients in observation group was much higher than that in control group (P<0.05). There were no statistical differences appeared after comparison between the control group and observation group with the cases of adverse drug reaction. Conclusion: Bifid triple viable capsules had significant clinical curative effect on UC with high security, whose mechanism of action may have close effect on reducing serum hs-CRP and PCT levels and inhibiting intestinal mucosal inflammation. |
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