| ABSTRACT Objective:To compare clinical efficacy of continuous intravenous insulin infusion and continuous subcutaneous insulin infusion in treatment of diabetic ketoacidosis. Methods:Totally 50 cases of patients with diabetic ketoacidosis were randomly divided into observation group and control group. Control group was treated by continuous intravenous insulin infusion, while observation group was treated by continuous subcutaneous insulin infusion. Fasting and postprandial blood glucose levels, oxidative stress related indicators of patients in two groups were monitored. Blood glucose target time, dosage of insulin, the urine acetone bodies' extinction time, pH recovery time and incidence of complications of patients in two groups were compared. Results:Blood glucose target time in observation group was significantly shorter than that in control group （P＜0.05）. Dosage of insulin, the urine acetone bodies' extinction time and pH recovery time in observation group were significantly lower than those in control group （P＜0.05）.After treatment ，SOD，MDA，GSH PX and TAC levels of patients in observation group were significantly better than before treatment and control group （P＜0.05）. Total incidence of complications in observation group was significantly lower than that in control group （P＜0.05）. Conclusion:Continuous subcutaneous insulin infusion in treatment of diabetic ketoacidosis could reduce dosage of insulin, shorten blood glucose target time, the urine acetone bodies' extinction time and pH recovery time, and reduce incidence of complications. It was worthy of wide spread application in clinical practice. |
