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| 卡培他滨治疗胃癌疗效及安全性的系统评价 |
| Systematic Review on Therapeutic Effect and Safety Evaluation of Capecitabine in Patients with Gastric Carcinoma |
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| DOI： |
| 中文关键词: Meta分析 胃癌 卡培他滨 药品安全性 随机对照实验 |
| 英文关键词:Meta analysis Gastric carcinoma Capecitabine Drug safety Randomized controlled |
| 基金项目:国家社科基金资助项目(编号:13BGL132) |
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| 中文摘要: |
| 摘 要 目的:系统评价胃癌患者使用卡培他滨的疗效和安全性。方法：检索国内外发表的关于卡培他滨治疗胃癌的中英文文献，对符合纳入标准的随机对照试验进行系统评价。结果：最终纳入8篇文献，合计427例患者。卡培他滨单药与替吉奥、多西他赛+顺铂比较疗效，差异无统计学意义（P>0.05）。卡培他滨单药发生口腔黏膜炎（26.7%）和手足综合症（49.8%）的频率较高；替吉奥给药方案与卡培他滨单药相比毒性小；多西他赛+顺铂给药更易发生恶心/呕吐（P<0.05；卡培他滨+奥沙利铂给药更易发生白细胞减少（P<0.05）；FOLFOX4给药更易发生白细胞减少（P<0.05）和恶心/呕吐（P<0.05）。结论：常规剂量下替吉奥与卡培他滨单药相比毒性更小，卡培他滨发生口腔黏膜炎和手足综合征的频率较高。总体而言，卡培他滨单药给药安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: Systematically review on therapeutic effect and chemotherapy safety of capecitabine in the treatment of the gastric carcinoma patients.Methods:Chinese and foreign related literature about capecitabine in the treatment of the gastric carcinoma patients were retrieved, systematic review of randomized controlled trial which was included in the studies. Results: 8 literature and about 427 patients were chosen from all the papers. Into the study through the analysis, there was no significant difference between capecitabine, S-1, docetaxel and cisplatin about the treatment effect（P>0.05）. Patients with capecitabine single agent, stomatitis（26.7%） and hand foot syndrome（49.8%） occurred more often; results were better when S-1 dosage regimen compared with capecitabine single agent, patients use capecitabine and cisplatin was more vulnerable to have nausea/vomiting（P<0.05）; leukopenia occurred more often when patient have capecitabine and oxaliplatin（P<0.05）, nausea/vomiting（P<0.05） and leukopenia（P<0.05） occurred more often when patient had FOLFOX4. Conclusion:Results were better when S 1 dosage regimen compared with capecitabine single agent. Stomatitis and hand foot syndrome occurred more often when used capecitabine. In conclusion, the safety of the capecitabine was acceptable. |
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