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| 双歧杆菌三联活菌散对轮状病毒性肠炎婴幼儿血清炎症因子的影响及疗效观察 |
| Influence and Curative Effect Observation of Live Combined Bifidobacterium, Lactobacillus and Enterococcus Powder on Serum Inflammatory Factors in Infants and Young Children with Rotavirus Enteritis |
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| DOI： |
| 中文关键词: 轮状病毒性肠炎 婴幼儿 双歧杆菌三联活菌散 白细胞介素-6 肿瘤坏死因子-α |
| 英文关键词:Rotavirus enteritis Infants and young children live combined bifidobacterium, lactobacillus and enterococcus powder IL-6 TNF-α |
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| 中文摘要: |
| 摘 要 目的:探讨双歧杆菌三联活菌散对婴幼儿轮状病毒性肠炎患儿血清炎症因子的影响及疗效。方法：74例婴幼儿轮状病毒性肠炎患儿随机分为观察组(37例)和对照组(37例)。两组患儿均予调整饮食、抗病毒、补液及预防和纠正电解质紊乱和酸碱失衡等常规治疗。观察组加用双歧杆菌三联活菌散温水冲服，连用72 h。观察两组患儿治疗前后血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平变化，比较两组临床疗效及药品不良反应。结果：治疗72h后，两组患儿血清IL-6和TNF-α水平均较前明显下降(P<0.05或P<0.01)，且观察组水平明显低于对照组(P<0.05)。观察组临床总有效率明显高于对照组(P<0.05)。两组患儿治疗期间未见药品不良反应。结论：双歧杆菌三联活菌散治疗婴幼儿轮状病毒性肠炎疗效显著，可能与明显降低血清IL-6和TNF-α水平，控制肠黏膜炎症反应，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective:To explore influence and curative effect observation of live combined bifidobacterium, lactobacillus and enterococcus powder on serum inflammatory factors in infants and young children with rotavirus enteritis. Methods:74 cases of infants and young children with rotavirus enteritis were divided into observation group(n=37 cases) and control group(n=37 cases) at random. The children in two groups were given medical treatment such as diet adjustment, anti virus, fluid infusion, prevention and adjustment of electrolyte disturbances and acid base imbalance and etc, and the children in observation group were additionally given live combined bifidobacterium, lactobacillus and enterococcus powder, with warm water for 72 h. The changes of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) indexes of children in two groups before and after treatment were observed and judged, and the clinical curative effect and adverse drug reactions were compared as well. Results:72 h after treatment, serum IL-6 and TNF-α indexes of children in two groups obviously declined (P<0.05 or P<0.01), and the declining rate of children in observation group was much higher than that in control group (P<0.05). Meanwhile, total clinical efficiency of children in observation group was much higher than that in control group (P<0.05). There was no obviously adverse drug reactions in two groups during treatment. Conclusion:The live combined bifidobacterium lactobacillus and enterococcus powder had significant curative effect on infants and young children with rotavirus enteritis, whose mechanism of action may have close effect on obviously reducing serum IL-6 and TNF-α indexes levels and controlling intestinal mucosal inflammation. And it had high safty. |
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