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| 不同浓度他克莫司软膏治疗特应性皮炎疗效及对患者炎性因子水平影响 |
| Effect and Influence on Inflammatory Factors ofDifferent Concentrations of Tacrolimus Ointment inPatients with Atopic Dermatitis |
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| DOI： |
| 中文关键词: 他克莫司 特应性皮炎 白细胞介素-6 白细胞介素-10 |
| 英文关键词:Tacrolimus ointment Atopic dermatitis Interleukin-6 Interleukin-10 |
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| 中文摘要: |
| 摘 要 目的:比较不同浓度他克莫司软膏对特应性皮炎患者白细胞介素-6（IL-6）和白细胞介素-10（IL-10）表达水平的影响，及其疗效与安全性。方法：特应性皮炎患者96例随机分为观察组（0.1%他克莫司软膏外涂皮损部位，早晚各1次）和对照组（0.03%他克莫司软膏外涂皮损部位，早晚各1次），两组疗程均为3周。比较两组患者治疗前后血清IL-6、IL-10水平，皮损的面积、症状、体征及药品不良反应，评估患者临床疗效。结果：观察组总有效率为97.92%，明显高于对照组的79.17%（P＜0.05）。治疗后，两组患者严重指数（EASI）、受累面积占体表面积百分比(BSA)和体征／瘙痒症状评分均较治疗前下降（P＜0.05）；且观察组下降值均大于对照组（P＜0.05）。治疗后两组血清IL-6、IL-10水平均较前明显降低（P＜0.05）；且观察组明显低于对照组（P＜0.05）。两组药品不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：采用0.1%他克莫司软膏用于治疗特应性皮炎疗效优于0.03%他克莫司软膏，能显著改善患者皮损情况和症状体征，降低血清IL 6和IL 10水平，且安全性好。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the effect and safety on different concentrations of tacrolimus ointment forpatients with atopic dermatitis，and the influence on the level of serum levels of interleukin（IL）-6 and IL 10. Methods:96 patients with atopic dermatitis were divided into the observation group (0.1% tacrolimus ointmentgently applied on the affected area twice a day, morning and evening for 3 weeks) and the control group (0.03% tacrolimus ointment gently applied on the affected area twice a day, morning and evening for 3 weeks)at random. The serum levels of IL-6 and IL-10, the psoriasis area, symptoms, signs before and after treatment and the adverse drug reactionsof the two groups were compared，and the effect of two groups were evaluated. Results: The effective rate of the observation group was 97.92%, much higher than that of the control group (79.17%，P＜0.05). After treatment，the scores of EASI、BSA% and signs in the two groups were both decreased significant than before(P＜0.05), the loss of the observation group was more than the control group（P＜0.05）. After treatment，the serum level of IL-6、IL-10 of the two groups were both lower than before （P＜0.05），and levels of the observation group were much lower than that of control group （P＜0.05）. There was no significant difference in the incidence rate of adverse drug reactions（P＞0.05）. Conclusion:The clinical effect of 0.1% tacrolimus ointment was better than 0.03% tacrolimus ointment. Itcould improve the lesions, symptoms and signs and reduce the level of IL 6 and IL 10.Also, it had good safty. |
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