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| 左氧氟沙星注射液不良反应影响因素的Logistic回归分析 |
| Logistic Regression Analysis on Influential Factors of ADR Caused by Levofloxacin Injection |
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| DOI： |
| 中文关键词: 左氧氟沙星注射液 药品不良反应 影响因素 Logistic回归分析 |
| 英文关键词:Levofloxacin injection Adverse drug reaction Influential factors Logistic regression analysis |
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| 中文摘要: |
| 摘 要 目的:探讨左氧氟沙星注射液不良反应( ADR)发生情况及其影响因素，提高临床用药安全性。方法：回顾性分析1 748例左氧氟沙星注射液治疗的患者临床资料，统计ADR发生的发生特点和发生率，采用单因素分析和多因素Logistic回归分析评价其影响因素。结果：发生ADR共计48例，ADR发生率为2.75%。多因素Logistic回归分析显示ADR的独立危险因素有年龄(OR=1.687, 95%CI：1.447～1.967)、过敏史(OR=2.257, 95%CI ：1.898～2.684)、用药剂量(OR=1.815, 95%CI：1.582～2.082)、疗程(OR=1.783, 95%CI：1.516～2.097)和联合用药(OR=1.729, 95%CI：1.488～2.009)。结论：左氧氟沙星注射液ADR发生临床症状较轻，但累及器官和系统广，并且与年龄、过敏史、用药剂量、疗程和联合用药有关。临床医生必须根据这些因素，提高用药注意事项，以降低ADR风险。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the adverse drug reactions (ADR) of levofloxacin injection and the related risk factors, in order to improve clinical medication safety. Methods:The clinical data of 1 748 cases treated with levofloxacin injection were reviewed. The kinds of ADR and their incidences were investigated. And the risk factors were analyzed by single factor and multivariate Logistic regression analysis. Results: The ADR were found in 48 cases, and the incidence of ADR was 2.75%. Multivariate logistic regression analysis showed that independent risk factors for ADR were as follows: age (OR=1.687, 95%CI:1.447-1.967), allergic history (OR=2.257, 95%CI:1.898-2.684), dosage of medication (OR=1.815, 95%CI:1.582-2.082), course of treatment (OR=1.78, 95%CI:1.516-2.097) and drug combination (OR=1.729, 95%CI:1.488-2.009). Conclusion:The levofloxacin injection had milder adverse reaction, involving many organs and systems. It related to age, allergic history, dosage of medication, course of treatment and drug combination. Clinicians must improve medical attention based on these factors in order to reduce the incidence of ADR. |
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