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| 依达拉奉联合常规治疗对急性脑梗死患者神经功能的影响 |
| Influence of Edaravone plus Regular Treatment on Neural Function in Patients with Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 依达拉奉 急性脑梗死 神经功能 超氧化物歧化酶 神经元特异性烯醇化酶 丙二醛 |
| 英文关键词:Edaravone Acute cerebral infarction Neural function Superoxide dismutase Neuron specific enolization enzyme Malondialdehyde |
| 基金项目:2012丽水市公益性应用技术项目（编号：2012JYZB16） |
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| 中文摘要: |
| 摘 要 目的:观察依达拉奉联合常规治疗对急性脑梗死患者神经功能的影响。方法：144例急性脑梗死患者随机分为观察组(n=72)和对照组(n=72)，对照组给予常规治疗，观察组在常规治疗基础上加用依达拉奉，疗程2周。比较两组患者治疗前后的血清超氧化物歧化酶(SOD)、血清丙二醛(MDA)和神经元特异性烯醇化酶(NSE)水平变化，根据美国国立卫生研究院卒中量表(NIHSS)评定两组神经功能缺损。结果：治疗后两组的NIHSS评分均较治疗前明显降低(P<0.05)，观察组治疗后评分明显低于对照组(P<0.05)。治疗后两组患者血清SOD水平均较治疗前明显升高，MDA和NSE水平则明显降低(P<0.05)；且治疗后两组患者SOD、MDA和NSE水平比较，差异有统计学意义(P<0.05)。两组药品不良反应发生率比较，差异无统计学意义(P>0.05)。结论：依达拉奉能明显改善急性脑梗死患者的神经功能，其作用机制与清除自由基、降低神经元特异性烯醇化酶有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of edaravone on neural function in patients with acute cerebral infarction. Methods:144 cases with acute cerebral infarction were randomly divided into observation group (n=72) and control group (n=72). The control group were treated with conventional therapy, and the observation group were given edaravone additionally for 2 weeks. The levels of serum superoxide dismutase (SOD), serum malondialdehyde (MDA) and neuron specific enolization enzymes (NSE) of the two groups were compared. The neurologic impairment of the two groups were evaluated by National Institute of Health stroke scale (NIHSS).Results:The NIHSS scores in both the two groups were lower after treatment than baseline(P<0.05), and the observation group changed more than control group (P<0.05). After treatment in both the two groups the levels of SOD were increased, the levels of MDA and NSE were decreased, which were all produced siginificant differences (P<0.05); furthermore, the observation group changed more than control group in all the three indicators (P<0.05). The incidences of adverse drug reactions showed no significant difference in two groups(P>0.05). Conclusion:Edaravone could obviously improve neural function in patients with acute cerebral infarction, which might be related to scavenging free radicals and reducing neuron specificity enolization related enzymes. |
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