| ABSTRACT Objective: To discuss the prevention and mechanism of probiotics on intestinal nutrition related diarrhea in patients with chronic obstructive pulmonary disease (COPD). Methods:66 cases with COPD, who were given mechanical ventilation medical treatment, were divided into observation group (n=33) and control group (n=33) at random. The patients in two groups were given isonitrogenous and isocaloric nutrition support, enteral nutrient solution could be nasal feed. The patients in observation group were additionally given 630mg bifid triple viable capsules, which were added to intestinal nutrition fluid, twice a day, for 10 days. The occurrence rates of diarrhea, alteration of intestinal flora, reaching standard amount of enteral nutritin and plasma D-Lactic and secretory IgA (SIgA) levels in the stool of patients in two groups after 10 day’s medical treatment were compared.Results:The occurrence rates of diarrhea and alteration of intestinal flora of patients in observation group and reaching standard amount of enteral nutritin were much lower than those in control group(P<0.05). After the treatment, the plasma D-Lactic levels of patients in observation group were obviously decreased than before (P<0.05), the SIgA levels of patients in observation group were obviously increased than before (P<0.05), while the plasma D-Lactic and SIgA levels of patients in control group showed no obvious changes before and after treatment (P>0.05). Conclusion:The probiotics had reliable curative effect on the prevention of intestinal nutrition related diarrhea of patients with COPD, and could reduce occurrence rates of diarrhea and alteration of intestinal flora, decrease plasma D-Lactic level and increase the secretion of intestinal SIgA level, whose curative effect had close effect on decreasing plasma D-Lactic level and increasing intestinal SIgA level. |
