| ABSTRACT Objective:To study the risk factors of adverse drug reaction (ADR) of cefoperazone/tazobatam. Methods:64 cases report of cefoperazone/ tazobatam ADR were collected (2006 2014) from one province center for adverse drug reaction monitoring. 128 patients who received cefoperazone/tazobatam treatment and has not appeared ADR during the course of hospitalization (2014.11-2015.8) were selected for control. Suspected ADR risk factors were statistical analysis by chi square test and conditional logistic regression, such as gender, age, medication time, past medical history and original disease. Results:Univariate analysis indicated that the occurrence of adverse reactions relate to the patient’s gender, age, the length of medication use, the original disease and past medical history. The result of conditional logistic regression multivariable analysis indicated that age, personal history, medication time, and original disease are the ADR risk factors of cefoperazone/tazobatam. Medication time was analyzed by univariate analysis, ADR of cefoperazone/tazobatam was 70.8% appear within 72 hours. Analyse the time of ADR of cefoperazone/tazobatam, find ADR of cefoperazone /tazobatam appear within 72 h and after 72h did not have statistical differences in gender, administration route, past medical history and the original disease(P>0.05), only have statistical different in age(P<0.05). Conclusion:ADR risk factors of cefoperazone /tazobatam were medication time, dosage of administration and past medical history. |
