| ABSTRACT Objective:To evaluate the relationship between upper gastrointestinal bleeding (UGIB) and different drugs such as traditional Chinese medicine injection having the effect for dispersing blood stasis, spironolactone and heparin etc. Methods:Case group consist of 912 patients who were diagnosed UGIB . Control group were matched with gender of case group, consisting of 1824 patients who were in the same period without gastrointestinal bleeding. The clinical characteristics and differences of used medicines concerned with UGIB were compared in this study, and suspected adverse drug reaction(ADR) risk factors were statistical analysis by logistic regression. Results:The OR of UGIB among traditional Chinese medicine having the effect for dispersing blood stasis, spironolactone, heparin, aspirin, clopidogrel, warfarin, NSAIDs, steroids were 1.630, 2.748, 3.488, 1.603, 1.787,6.646, 5.787 and 3.382 respectively. The OR of PPI and H2 receptor antagonist respectively were 0.025 and 0.018. All of these drugs above were factors affecting UGIB (P＜0.05). However, calcium channel blockers and nitrate were not factors affecting UGIB( P＞0.05). The proportion of old age（≥65 years old）, H. Pylori (Hp) infection, history of gastrointestinal bleeding(GIB), peptic ulcer, chronic gastritis, chronic duodenitis, diabetes and cancer in case group were larger than control group. Conclusion:The use of traditional Chinese medicine having the effect for dispersing blood stasis, spironolactone and heparin would result in UGIB. Meanwhile, old age（≥65 years old）,Hp infection, history of GIB, peptic ulcer, chronic gastritis, chronic duodenitis, diabetes and cancer were risk factors of UGIB. |
