| ABSTRACT Objective:To analyze the characteristics of adverse drug reactions（ADR） of the elderly, and provide reference for clinical rational drug use.Methods:The data of ADR/adverse drug events（ADE）reporting in the elderly was analyzed such as patient sex, drug categories, route of administration, time of ADR/ADE occurred and ADR involving organ/system, based on PIM of ADR/ADE in Xiaogan city from 2011 to 2014. Results:A total of 1 721 ADR/ADE primary disease reported, respiratory disease 516 cases (29.98%), 387 cases of cardiovascular disease (22.49%), 230 cases of gastroenterology disease (13.37%).In suspected drug of ADR / ADE, the antimicrobial agents 769 cases (44.68%), the main kinds were levofloxacin(156 cases), cefoperazone/sulbactam(81 cases), ceftriaxone(74 cases); 342 cases of Chinese traditional medicine injections(19.87%), the main kinds were Shenmai injection (86 cases), Xiangdan injection (48 cases) and Xuesetong injection (36 cases). The main dosage form was injection 1 398 cases (81.23%); intravenously 1 302 cases (75.65%). 863 cases of ADR (50.15%) occurred within 1h after injection. Involving systems / organs mainly in the skin and appendages (445 cases, 25.86%), digestive damage (349 cases, 20.28%) and allergic reactions (219 cases, 12.73%) dominated. PIM drugs involved ADR/ADE 23 species, 135 cases (7.84%), mainly drugs are clindamycin (67 cases). Conclusion:It was important to pay more attention to ADR of antibacterial drugs and TCM injections and prevent allergic reactions of drugs. The elderly avoid using PIM directory drugs, so as to guarantee drug safety. |
