| ABSTRACT Objective:To study the curative effect of high dose intravenous immunoglobulin on the prevention of bronchiolitis developing into asthma.Methods:158 cases of children with bronchiolitis were randomly divided into observation group and control group, 79 cases in each group.The control group was given routine treatment of anti infection, cough and asthma，the observation group was given intravenous injection of gamma globulin protein 1.0 g·kg-1·d-1 additionally, on the basis of the control group.After 2d’s treatmen，the main symptoms disappeared time, hospitalization time, efficiency and adverse reaction rate of the two groups were observed and compared, and the incidence of asthma of the two groups after 1 year’s follow up were observed.Results:After treatment, the total effective rate of the observation group was 96.2%, significantly higher than that of the control group(77.2%，P<0.05). The dyspnea disappearance time, pulmonary rales disappeared time and hospitalization time of observation group were significantly shorter than the control group （P＜0.05).After the follow up period, the incidence of asthma in the observation group was significantly lower than that in the control group （P＜0.05). There was no significant difference in adverse drug reactions between the two groups(P＞0.05). Conclusion:Useing high dose intravenous immunoglobulin on the basis of conventional therapy on prevention of bronchiolitis developing as an asthma，it has significant preventive effect, is worth popularization and application. |
