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某院2014年药品不良反应报告回顾性分析

Retrospective Analysis of Adverse Drug Reaction Reports in a Hospital During 2014

DOI：

中文关键词: 药品不良反应；回顾性分析报告；监测；安全用药

英文关键词:Adverse drug reaction Retrospective analysis Reports Mornitering Safety use of drug

基金项目:

作者	单位
白娟^①② 李龙^①② 宋融^③ 闫丹^② 乔逸^② 文爱东^②	①陕西中医药大学药学院（陕西咸阳 712046）；②第四军医大学西京医院药剂科；③西安医学院。

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中文摘要:

摘要目的：了解某院药品不良反应（ADR）发生特点，为临床安全用药提供参考。方法：采用回顾性分析方法对某院2014年上报的366份ADR报告进行统计分析。结果：发生ADR的患者年龄分布以51～60岁最多，女性（52.2%）多于男性（47.8%）；发生ADR的怀疑药物主要为抗肿瘤药物，其次为抗感染药物；ADR所累及器官以消化系统损害为主。366例ADR报告中，新的ADR 5例，严重的ADR 19例，新的和严重的ADR仅占总报告数的6.6%。关联性评价结果显示，评价为很可能的病例报告最多（237例），占总数的64.8%。结论：引起ADR的怀疑药物以抗肿瘤药物及抗感染药物为主，因此应该重视该类药物的管理，积极进行ADR监测，减少ADR的发生，促进临床用药安全。

英文摘要:

ABSTRACT Objective:To study the characteristics of adverse drug reactions in a hospital, provide a reference for clinical rational drug use. Methods:A retrospective analysis of a hospital in 2014 reported 366 adverse reaction reports for statistical analysis.Results:ADR occurred in patients with age distribution up to 51 60 years old, females (52.2%) overall than men (47.8%); A hospital adverse reactions of drugs, primarily for the anti tumor drugs, followed by anti infectives; for adverse reactions involving damage to the main organs in the digestive system.Within the 366 cases of ADR reports, the new ADR was 5 cases, 19 cases of severe ADR, new and severe ADR accounted for only 6.6% of the total number of the report. The relevance evaluation result showed that the most likely case report (237 cases) was the most, which was64.8% of the total.Conclusion:Adverse reactions to anti tumor drugs and anti infectives, hence should pay attention to the management of these drugs, active drug monitoring, thereby reducing the incidence of adverse reactions, the promotion of rational drug use.

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