| ABSTRACT Objective:To discuss curative effect of zoledronic acid combined with percutaneous kyphoplasty(PKP) on vertebral compression fractures (VCF) in elderly patients and its influence on bone density and bone metabolism.Methods:70 cases of elderly patients with VCF were divided into observation group and control group at random. The patients in two groups were given PKP, while the patients in observation group were additionally given 5mg zoledronic acid by intravenous drip on the third day after operation. The visual analogue scale (VAS) and Oswestry disability index score (ODI) were made before the operation, and 24 hours, 6 months and 12 months after the operation, as well as bone density with bone specific alkaline phosphatase (BAP) and type I Pro collagen peptide (CTX) before and 12 months after the operation. The curative effect and bone density with bone metabolism of patients in two groups were compared, and the adverse drug reaction were observed as well. Results:The VAS and ODI scores of patients in two groups 24 hours, 6 months and 12 months after the operation were all improved than before (P<0.05 or P<0.01), and the scores of patients in observation group was much lower than those in control group (P<0.05). At 12 months postoperatively, bone density of patients in observation group was improved than before (P<0.05), the serum BAP and CTX compared with the preoperative decreased significantly (P<0.05), and all index were better than control group(P<0.05); while there were no significant changes appeared on patients in control group before and after treatment (P>0.05). While campared the incidence of adverse drug reaction in two groups, the differance had no statistical significance(P＞0.05). Conclusion:The application of zoledronic acid combined with PKP had favorable curative effect on VCF in elderly patients, and could improve bone density, reduce the serum level of BAP and CTX, it had good safety. |
