| ABSTRACT Objective:To observe the influence on the level of blood glucose in patients with type 2 diabetes mellitus treated by sitagliptin combined with glargine insulin and its clinical efficacy and safety. Methods:66 patients with 2 type diabetes were randomly divided into the observation group，which were treated with sitagliptin combined with glargine insulin，and control group, which were treated with premixed insulin. After 3 months of treatment，the changes of blood glucose levels，blood pressure and blood lipid of the two groups before and after treatment were compared, and the clinical effect and adverse drug reactions of the two groups were evaluated. Results: In addition to low blood sugar AUC, the blood glucose level, FBG, PBG, glycosylated hemoglobin, the average blood glucose levels within 72h, SDBG, MAGE, MODD and high blood sugar AUC of observation group were better than before (P<0.05), and better than the control group (P<0.05). The blood pressure and blood lipids in the two groups were no significantly different before and after treatment (P>0.05), but the BMI index of the observation group was significantly lower than that of the control group after treatment (P<0.05). The difference of the total effective rate of the two groups was no statistically significant（P>0.05). The incidence of adverse drug reactions in the observation group was significantly lower than that of the control group (P<0.05). Conclusion: Sitagliptin combined with glargine insulin could significantly reduce the blood glucose levels in patients with type 2 diabetes, the adverse drug reaction was mild. With the exact effect and the high safety, it should be widely used in clinical. |
