| ABSTRACT Objective: To investigate drug resistance of pathogens causing urinary tract infection to ceftriaxone in the recent five years. Methods: the references related to drug resistance of pathogens causing urinary tract infection to ceftriaxone were retrieved through CNKI database. The resistance rates and sensibility rates of different types of bacteria were classified, calculated, and analyzed. And the Kendall correlation coefficient was also calculated.Results:36 references were screened out , and statistical analysis showed that the main pathogen detected in the urine was Escherichia coli (64%), followed by Klebsiella pneumoniae (18%). In addition to Proteus mirabilis, the drug resistance rate of detected bacterias was over 50% to ceftriaxone, while the drug resistance rates of Enterobacter cloacae, Acinetobacter baumannii and Pseudomonas aeruginosa were more than 75%. According to the Kendall correlation coefficient（τ）, the resistance rates of Escherichia coli and Klebsiella pneumoniae to cefotaxime and ceftriaxone were highly correlated, especially that from the ESBLs producing Escherichia coli and Klebsiella pneumonia. Conclusion:The resistance rates of pathogens causing urinary tract infection to ceftriaxone displayed an upward tendency. The mechanism of resistance to strains was mainly involved in producing ESBLs . Which indicated that ceftriaxone and β lactamase compound preparations may become the best choice for the treatment of the infection of ceftriaxone drug resistant strains. |
