| ABSTRACT Objective: To investigate the therapeutic function and curative effect of fluorine methods material and modified chitin xanthan gumin treatment of patients with oral helicobacter pylori (Hp) infection.Methods:618 patients with oral Hp infection and without symptom of digestive tract were randomly divided into two groups: observation group (310 cases) and control group (308 cases). The observation group used non drug toothpaste combined with fluorine methods material for brushing test. Among which 82 cases with oral cavity ulcer additionally received modified chitin xanthan gum spray on oral ulcer. The latter (308 cases) used blank toothpaste as a control, cleaning the mouth with toothpaste after dinner every day.The Hp positive rate, average Hp eradication time and indicators such as oral cavity ulcer healing condition in two groups were compared. Results:In the treatment of after 30 d, 90 d, the oral Hp positive rate of observation group and control group was 53.55%,98.70% and 7.94%,94.59%, the difference was statistically significant ( P<0.01 ). In the respect of treatment of oral ulcer, after 7 days and 30 days, the effective rate of observation group and control group was 76.74%,15.19% and 100%,32.91%, the difference was statistically significant ( P<0.01 ). There had no severe adverse reactions occurred in the process of treatment in observation group.Conclusion:Fluorine methods material could effectively decrease the positive rate of oral Hp infection, the treatment combinded with modified chitin xanthan gum could shorten the time of oral ulcer healing, it had important value to control the oral Hp infection. |
