|
| 替加环素治疗ICU广泛耐药鲍曼不动杆菌感染临床分析 |
| Clinical Analysis of Tigecycline Treatment in Infections Caused by Extensively Drug resistant Acinetobacter Baumannii in ICU |
| |
| DOI： |
| 中文关键词: 广泛耐药 鲍曼不动杆菌 重症监护病房 感染 替加环素 |
| 英文关键词:Extensively drug resistance Acinetobacter baumannii Intensive care units Infection Tigecycline |
| 基金项目:国家“十二五”科技重大专项（编号：2013ZX09303005） |
|
| 摘要点击次数: 1616 |
| 全文下载次数: 2469 |
| 中文摘要: |
| 摘 要 目的:回顾性分析替加环素治疗广泛耐药鲍曼不动杆菌(XDRAB)的微生物学清除率及临床治疗效果。方法：选择我院重症医学科2013～2014年29例确诊为XDRAB感染并单用或联合使用替加环素治疗的患者的病历资料。替加环素首剂100 mg，随后每12 h 50 mg ivd，疗程≥3 d，收集其临床及微生物学相关资料。结果：29例XDRAB感染患者应用替加环素治疗后，11例(37.9%)临床治疗有效，8例(27.6%)微生物清除。10例(34.5%)因临床和细菌学反应差而在2周内死亡。替加环素联合头孢哌酮/舒巴坦的临床有效率75%，优于其他方案。结论：替加环素联合头孢哌酮/舒巴坦治疗XDRAB感染效果较好。 |
| 英文摘要: |
| ABSTRACT Objective: AIM To evaluate the efficacy of tigecycline in patients with extensively drug resistant Acinetobacter baumannii (XDRAB) infection. Methods:A retrospective analysis was conducted in adult 29 patients with proven XDRAB infection treated with tigecycline alone or combined between January 2013 and December 2014. The first dosage was 100mg, then every 12 h 50 mg intravenous drip, for more than 3 days. The clinical and microbiological related information were collected. Results:After the treatment of tigecycline in 29 XDRAB infection cases, there were 11 patients (37.9%) showed clinical effective while microbiological eradication was achieved in 8 patients (27.6%). 10 cases (34.5%) died within 2 weeks due to the ineffectiveness of clinical treatment and bacteriological responses. Tigecycline combined with cefoperazone/sulbactam was more effective (75%) than other tigecycline based therapies.Conclusion:Tigecycline combined with cefoperazone/sulbactam had a better effect for treating patients with extensively drug resistant Acinetobacter baumanni. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
