| ABSTRACT Objective:To analyze the characteristics of adverse drug reaction(ADR) related to hematological system drugs and provide references for the clinical rational drug use. Methods:The ADR reports of hematological system drugs were collected from 2009 to 2014 in the database of PLA ADR monitoring center and analyzed retrospectively. Results: Among the 5 073 ADR cases, the male to female ratio was 1.31∶1,the average age was（51.4±19.2）years, mainly in young people (31.45%) and middle aged (28.92%), and with a single drug cause (81.27%).The top three of suspected drugs were antiplatelet drugs（41.24%）, promote blood clotting drugs (31.20%) and plasma and plasma substitute (11.47%).Injection accounted for 88.76%. Intravenous drip (78.56%) was the main route of administration. Alprostadil (25.26%),tranexamic acid (22.42%), and dextran 40 (6.63%) were the top three among suspected drugs. ADRs mainly involved the digestive system damage (28.69%), cardiovascular system damage(22.51%) and the skin and its appendages damage(16.51%). Main manifestations of ADRs were nausea, vomiting, phlebitis, rash and so on. Main manifestation of new and severe ADRs were abnormal blood pressure and anaphylactic shock. Conclusion:The rational use of hematological system drugs needs attention. ADR monitoring should be strengthened in order to prevent or avoid medication related risks. |
