| ABSTRACT Objective:To study the drug utilization and safety of deproteinized calf serum injection and to provide reference for its rational use. Methods:Adverse drug reaction (ADR) reports and drug utilization on deproteinized calf serum injection were collected from the adverse reactions center in Hubei province and Hospital information network in the Yangtze River Basin during the period of 2012 2014. These datas were classified and summarized in repsects of gener, age，occurrence time，clinical manifestation，outcome，utilization, etc.Results:Deproteinized calf serum injection induced ADR had no significant gender differences, with higher incidence rate in the population aged 51-60, accounting for 32.94%. ADR mainly occurred within 60 min (47.06%), which involved the main system and organs were skin and accessory damage (50.00%) and systemic damage (18.26%). The main clinical manifestations were rash, pruritus, urticaria, chills, fever. The annual sale amounts and DDDs of deproteinized calf serum injection were increased gradually from 2012 to 2014. Conclusion:The clinical use of deproteinized calf serum injection continued to increase. However, ADR reports exposed that this drug exists certain risk, which needed to be paid more attention, and to further evaluate its efficacy and safety. |
