| ABSTRACT Objective: To evaluate the effect of intensive insulin treatment combined with sitagliptin on patients with newly diagnosed type 2 diabetic. Methods: 120 newly diagnosed type 2 diabetic patients were randomly divided into two groups，group Awas treated with intensive insulin alone, group B was treated with intensive insulin combined with sitagliptin. The FPG, 2hFPG, HbA1c, TG, TC, LDL, HDL, HOMA-β, HOMA-IRand frequency of hypoglycaemia of two groups were compared after 12 weeks treatment. Results: After treatment，the FPG, 2hFPG, HbA1c, TG, LDL and HOMA-IRof the two groups were all decreased significantly than before (P<0.05), while the HDL and HOMA-β were increased significantly (P<0.05), and the TC and LDL showed no obvious changes (P＞0.05). After treatment，the FPG, 2hFPG,HbA1c and TG of group B were all lower than those of group A significantly (P<0.05), while HOMA-β was higher than group A (P<0.05), and LDL, HDL, TC and HOMA-IRshowed no obvious differences (P＞0.05). The frequency of hypoglycaemia of group B was lower than group A significantly (P<0.05). Conclusion:The combination of intensive insulin treatment with sitagliptin can not only control the blood glucose level, but also decrease the frequency of hypoglycaemia, improve the islet β-cell function, and play a certain role in reducing blood lipid. |
