| ABSTRACT Objective:To study on the therapeutic effect of levocarnitine injection combined with nicorandil tablets on patients with unstable angina pectoris.Methods:120 patients with unstable angina were randomly divided into three groups, 40 cases in the control group, nicorandil group 40 cases, nicorandil combined levocarnitine group 40 cases. The three groups were given conventional treatment of coronary heart disease, nicorandil group and routine treatment for oral nicorandil tablets 5mg tid, period of treatment was 30 days. Nicorandil combined levocarnitine group in addition to conventional treatment, treated with nicorandil tablets orally 5mg tid, period of treatment was 30 days, while addition of levocarnitine injection 20 mg·kg-1·d-1 intravenously for 14 days, the three groups were observed for 30 days. Blood lipid parameter, left ventricular end diastolic diameter and left ejection fraction, relieving angina pectoris symptom changes of electrocardiogram, adverse drug reactions and major adverse cardiac events were compared before and after the treatment.Results:Compared with the control group and nicorandil group, combined treatment group can significantly improve the symptoms of angina pectoris and significantly reduce the incidence of major adverse cardiac events(P<0.05). The TC,LDL,TG of combination therapy group were below the other two groups and HDL was higher than the other two groups (P<0.05). To improve the degree of angina pectoris combined treatment group and nicorandil group was better than the control group (P<0.05). The occurrence rate of cardiovascular event in combined treatment group and nicorandil group were lower than control group(P<0.05). Conclusion:Levocarnitine injection combined nicorandil tablets in treatment of unstable angina pectoris, could significantly improve the clinical total effective rate and was safe and reliable. It provideed a new idea for clinicians treating unstable angina pectoris. |
