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| 拉莫三嗪单药治疗老年癫痫部分性发作的疗效观察 |
| Curative Effect of Lamotrigine Monotherapy for Focal Epilepsy in Elderly |
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| DOI： |
| 中文关键词: 拉莫三嗪 老年患者 癫痫部分性发作 继发全面性发作 疗效 安全性 |
| 英文关键词:lamotrigine Elderly patient Partial epilepsy seizure Secondarily generalized tonic clonic seizure Curative effect Safety |
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| 中文摘要: |
| 摘 要 目的:观察拉莫三嗪(LTG)治疗老年癫痫部分性发作（PS）或继发全面性发作（SGTCS）的疗效和安全性。方法：80例老年PS或SGTCS患者随机分为观察组和对照组，每组40例。观察组患者口服拉莫三嗪治疗12个月，对照组口服丙戊酸钠治疗12个月。观察两组患者的疗效和安全性。结果：观察组总有效率为92.5％,高于对照组的77.5％；药品不良反应发生率为7.5%，低于对照组的15.0%，差异均有统计学意义(P＜0.05)。结论：拉莫三嗪治疗老年癫痫PS或SGTCS癫痫安全、有效。 |
| 英文摘要: |
| ABSTRACT Objective:To observe the curative effect and safety of lamotrigine for partial seizures epilepsy(PS) and secondary generalized tonic clonic seizure(SGTCS) in the elderly. Methods:A total of 80 cases of PS and GTCS elderly were randomly divided into observation group and control group， with 40 cases in each group.The patients of observation group treated by lamotrigine in 12 months，patients of control group treated by valproate in 12 months. Curative effect and adverse drug reactions were observed after treatment in two groups.Results:The total effective rate was 92.5% in observation group，which was higher than the control group. And the adverse drug reactions rate of observation group was 7.5%, which was lower than the control group. Both of the differences were statistically significant(P＜0.05). Conclusion:Lamotrigine monotherapy was a safe and effective medicine for treating the PS and SGTCS in the elderly. |
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