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孟鲁司特联合常规治疗过敏性紫癜肾损害疗效观察

Efficacy of Montelukast Combined with Conventional Therapy for the Henoch Schnlein Purpura Children with Kidney Damage

DOI：

中文关键词: 过敏性紫癜肾损害孟鲁司特儿童

英文关键词:Henoch-Schnlein purpura Renal damage Montelukast Children

基金项目:

作者	单位
林志刚^① 潘慧^① 林忠响^①	①永康市第一人民医院小儿科（浙江永康 321300）

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中文摘要:

摘要目的：观察孟鲁司特联合常规治疗改善过敏性紫癜患儿肾损害的疗效和安全性。方法：过敏性紫癜肾损害患儿67例随机分为观察组(35例)和对照组(32例)。观察组给予孟鲁司特联合常规治疗，对照组仅予常规治疗。连续治疗2个月后，观察两组患儿血清胱抑素C(CysC)、血清β₂-微球蛋白(β₂-MG)、尿转铁蛋白(TRF)、尿微量白蛋白(mAlb)和尿β₂-MG水平变化，比较两组疗效。结果：观察组有效率为94.3%，高于对照组的75.0%（P＜0.05)。治疗后，两组患儿尿mAlb、β₂-MG、TRF水平与血β₂-MG、CysC水平均较治疗前明显下降（P＜0.05)；除两组血CysC水平差异无统计学意义(P＞0.05)外，观察组其他指标水平均明显低于对照组（P＜0.05)。结论：孟鲁司特联合常规治疗可明显提高疗效，改善患儿各项实验室指标。

英文摘要:

ABSTRACT Objective:To evaluate the safety and efficacy of montelukast combined with conrentional therapy treated Henoch Schnlein purpura children with kidney damage. Methods:Sixty seven children with Henoch Schnlein purpura were randomly divided into observation group(35 patients) and control group(32 patients). The observation group received montelukast combined with conventional therapy，the control group received only conventional therapy. Followed up the efficacy for 2 months, the change of serum CysC, serum β₂-MG, urine TRF, urine mAlb and urine β₂-MG were observed, and the curative effect was compared. Results:The curative effect of the observation group was 94.3%, which was higher than control group’s 75.0%（P＜0.05). The serum CysC, serum β₂-MG, urine TRF, urine mAlb and urine β₂-MG of two groups were decreased significantly than before（P＜0.05)；in addition to the blood levels of CysC between the two groups had no statistical significance (P＞0.05), other indicators level in observation group were significantly lower than the control group（P＜0.05).Conclusion:Montelukast combined with conventional therapy could improve the efficacy significantly, and lower the incidence rate of Henoch schnlein purpura nephritis.

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