| ABSTRACT Objective:To investigate the causes of cefoperazone /sulbactam induced nervous system adverse reactions so as to provide references for clinical safety use of drugs．Methods: From our hospital in January 2011 December 2012 cefoperazone sulbactam in patients with 1 141 cases, collect 105 cases of adverse reactions during the application process of cefoperazone /sulbactam ，including 33 cases of adverse reactions of the nervous system, By a retrospective study，investigate the analysis the 33 cases of adverse reactions of the nervous system.Results: In the 33 cases, 22 males and 11 females; The majority of patients over 60 years, a total of 30 cases, accounting for 90.9%. 33 patients to patient neurology and nephrology diseases majority, a total of 27 cases, accounting for 81.8%. Most of neurological adverse reactions occurred in the application of the conventional dose of cefoperazone/sulbactam treatment for 6 to 15 days, Followed by the administration more than 15 days. In those 33 patients, two cases combined with levofloxacin, and one case combined with cefoperozone. The clinical manifestations of nervous system adverse reactions to convulsions, involuntary jitter based, similar to the symptoms of epilepsy.Conclusion:Gender, age, underlying disease, time of administration and drug combination may have influence factors of Cefoperazone /Sulbactam cause nervous system adverse reactions. |
