| ABSTRACT Objective: To observe the influence of pidotimod combined montelukast with on T cell subsets in children with bronchiolitis obliterans. Methods:52 cases of children with bronchiolitis obliterans were ramdomly divided into observation group (26 cases) and control group (26 cases). The control group was given montelukast on the basis of the conventional treatment, the observation group was given pidotimod on the basis of the control group. Efficacy after treatment,disappear time of symptoms after treatment(shortness of breath ease, wheezing disappeared, cough disappears), signs (wheeze disappeared, auscultation disappear) and length of stay, and T cell subsets of two groups were compared. Results:After the treatment, the effective rate of the observation group(80.77%) was significantly higher than that of control group（P＜0.05); the disappearance time of symptoms,signs and hospital stays of observation group were shorter than those in control group（P＜0.05).After treatment, CD8+ ,CD8+ / CD8+ in two groups were higher than before treatment ,though CD8+ were decreased（P＜0.05); and the values in observation group were superior to the control group （P＜0.05).The incidence of adverse reactions of two groups had not statistically significant (P＞0.05). Conclusion:Pidotimod combined with montelukast has a good effect for children with bronchiolitis obliterans, it can improve T cell subsets, improve the symptoms and signs quickly, and has a good therapeutic effect. |
