| ABSTRACT Objective:Analysis of the adverse drug reactions’ general rules and characteristics which caused by calcium gluconate injection, in order to provide reference for clinical rational use of drugs. Methods:Using retrospective study method to statistics of ADR reports caused by calcium gluconate injection that were collected by Shandong Provincial Center for ADR Monitoring in National adverse drug reaction monitoring system during from January 1, 2010 to September 15, 2015. The items included patient gender and age, original disease, allergic history, reasons of medication, ADR occurrence time, method and dosage, combination medication, ADR involvement system organ type and clinical distribution, ADR outcome, and adverse reaction type, evaluation results and other factors.Results:Among the 268 ADR reports, the proportion of male and female patients were equal; 15 to 44 year old patients had the highest ratio; ADR mostly occurred during intravenous infusion; ADR occurred mostly within the first 30 min; clinical involvement organs or systems were mainly the gastrointestinal system, systemic reactions, and skin and its accessories; and most patients improved or were cured after drug withdrawal or symptomatic treatment. Conclusion:Pay attention to the adverse reactions caused by calcium gluconate injection. Supplement the safety information of instructions. Improve the level of clinical rational use of drugs. Strengthen the clinical monitoring. The purpose of these measures are preventing the serious adverse reactions and ensuring the safety of clinical medication. |
