| ABSTRACT Objective:To analyze the reasons and characteristics of serious adverse drug reactions (ADR)/adverse drug events (ADE) in The First Affiliated Hospital of Xi’an Jiaotong University, and provide reference for clinical rational drug use.Methods: All the clinical data were collected from 134 cases of serious ADR/ADE from 2008 2015 in the hospital. It was statistically analyzed from patients’ age, sex, types of drugs, clinical manifestations, the route of administration and the relevance of evaluation. Results:The proportion of men and women in serious ADR/ADE patients was 1.13∶1, the occurrence rate of serious ADR/ADE in elderly patients, anti tumor drugs and antimicrobial drugs were 37.31%, 37.31% and 22.39%, respectively. There were eight kinds of anti tumor drugs and three kinds of antimicrobial drugs in the 15 drugs of most frequently reported cases. The constituent ratio of intravenous infusion occurred ADR/ADE was reached to 85.4%. Clinical manifestations of serious ADR/ADE were mainly systemic damage, blood system damage and cardiovascular damage. Conclusion:We should pay attention to the monitoring of ADR/ADE of anti tumor drugs and antimicrobial drugs, improve the clinical safe, effective and rational use of drugs, reduce the risk of clinical ADR/ADE and ensure the drug safety of patients. |
