| ABSTRACT Objective:To observe the effect on the renal function of type 2 diabetes patients by using isotonic contrast agent(iodixanol) and low permeability contrast agents(iopromide).Methods:83 cases of diabetic patients with coronary artery angiography were randomly divided into iodixanol and iopromide group.The blood urea nitrogen（BUN）,serum creatinine（SCr） and urine micro albumin（mAlb） levels were detected in all patients at 1d before radiography,3d and 7d after angiography.The renal function indexes,incidence of contrast induced nephropathy and the adverse drug reaction were compared between the two groups. Results: Compared with before the contrast, the BUN,SCr and mAlb levels in the group of iopromide were significantly increased 3d after angiography(P<0.05); 7d after angiography, there was no significant difference in BUN,SCr and mAlb levels between the two groups(P>0.05). 3 days after coronary angiography, the SCr,BUN and mAlb level of the iodixanol group were significantly lower than that of the iopromide group(P<0.05); the incidence of adverse drug reactions and contrast induced nephropathy rate of the iodixanol group were significantly lower than those of the iopromide group(P<0.05).Conclusion:Compared with low osmolar contrast agent iopromide, using isotonic contrast medium iodixanol in patients with diabetes mellitus for coronary artery angiography, it had lower incidence of nephropathy, fewer adverse events shorter recovery period, worth a wide clinical application. |
