| ABSTRACT Objective:To investigate the risk factors which lead to mycophenolate mofetil(MMF) related adverse drug reactions after renal transplantation, to offer reference material about avoiding the MMF related adverse reactions for clinical. Methods:236 cases of kidney transplant patients were divided into bone marrow suppression, gastrointestinal tract reaction, infection group and control group. The age, gender, height, cadaveric kidney or living relative kidney, weight, BMI, dialysis time, transplanting time, history of diabetes or hypertension and history of hepatitis B or hepatitis C were collected. The oral daily doses and concentration of MMF at 3, 6, 12, 24, 36 months, as well as the plasma glucose (FPG), blood routine, blood lipids and the function of liver and kidney were recorded. All data were processed using statistical analysis. Results:According the general data contrast, there were significant difference in the BMI and medication time between the patients who had MMF related adverse reactions and the control group (P＜0.05). The dialysis time of the group of bone marrow suppression was much less than the control group, the difference was statistical significant (P＜0.05). And there was a statistical significance of the trough blood concentrations (C0) after three and six months postoperative between the group of bone marrow suppression and the control group (P＜0.05). The medication time （OR=4.016, 95%CI：1.035-10.517, P＜0.05）and the trough blood concentrations of MMF after 3 months postoperative (OR=1.104, 95%CI：1.001-3.218, P＜0.05) was the risk factors of bone marrow suppression.Conclusion:Logistic stepwise regression analysis showed that medication time and the trough blood concentrations of MMF after 3 months postoperative were the risk factors of bone marrow suppression coursed by MMF. That was, the longer the duration of medication, the higher the concentration of MMF after 3 months postoperative, the higher the risk of adverse reactions were. |
