| ABSTRACT Objective:To analyse the adverse reaction (ADR) of deproteinized calf blood extractives injection in Chengdu from 2014 2015, hoping to provide reference for rational use of deproteinized calf blood extractives injection. Methods:141 reports of ADR induced by deproteinized calf blood extractives injection received by Chengdu drug adverse reaction monitoring center were collected and analyzed during the period 2014 2015. Information about demographic,combination medication, dosage, administration, occurring time, manifestation, new/serious ADR, prognosis were retrieved and analyzed. Results:Among the 154 cases of ADR reports of deproteinized calf blood extractives injection which evaluated causality, 141 cases met the standard. The ADR mainly occured in adults and the elderly. Drug delivery way was intravenous drip, daily dose all conformed to the specification’s recommended dosage. The ADR reports involved in 25 cases of drug combination, 18 cases combined with TCM injections. The ADRs were mainly happened within an hour through intravenous infusion, the clinical manifestation involved different systems and organs. There were 7 serious ADRs, a total of 15 new ADR cases. Conclusion:The incidence of anaphylatic reaction and new ADR should be an important part of post marketing safety surveillance. Moreover, the quality of ADR reports should be assessed and evaluated. |
