| ABSTRACT Objective:According to analyzing the characteristics of the ADR/ADE caused by Danshen injection, provide reference information for clinical rational drug use. Methods:By a retrospective study, 561 cases with ADR/ADE induced by Danshen njection in Hubei province from January 2012 to December 2014, was analyzed with patient’s gender, age, occurrence time of adverse drug reaction/event (ADR/ADE), allergic history, clinical manifestations and prognosis.Results:Among the 561 cases with ADR/ADE, the male/female ratio was 1∶1.109, most of them (85.93%) were aged above 40 and the occurrence time of ADR/ADE cases mainly happened within 30 min after the treatment(56.86%). Totally 561 ADR/ADE cases were reported that mainly damaged in skin and its adnexa（34.31%）, systemic lesion（16.45%）, heart rate and rhythm disorders（12.76%）, etc. And the incidence of serious adverse reaction was 4.5%. Conclusion:Different degrees of ADR/ADE can be induced by Danshen njection, while enough attention should be paid to the clinical use of the injections. And ADR/ADE monitoring also should be strengthened to improve the safety of medication. |
