| ABSTRACT Objective:To investigate the main pathogens and their drug resistance in patients with hospital general surgery wound secretion isolated for clinical rational use of antimicrobial drugs to provide a scientific basis.Methods:The distribution and antibiotic resistance of Escherichia coli and the use of antimicrobial agents were analyzed retrospectively from 2013 to 2015.Results:During 2013 2015, the annual total amount of Escherichia coli in hospital wound secretions is greater than 1 000 strains, the extended spectrum β lactamase(ESBLs) producing strains accounted for more than 40.0%, and general surgical wound secretions Escherichia coli each year were greater than 63.0%, accounting for 40.0% of the total Escherichia coli strains; The positive rate of ESBLs producing strains was 30.0%；The hospital isolated Escherichia coli specimens mainly from the general surgical wound secretions, urine, blood and sputum, which general surgical wound secretion in the largest proportion; Every annual general surgery hospitalized patients antibacterial drugs use strength ranking top three were cefotaxime, cefoxitin, metronidazole; The Escherichia coli isolated from the wound secretions were highly resistant to ampicillin, cefazolin, ciprofloxacin, ceftriaxone, cotrimoxazole antimicrobial, with drug resistance rate more than 40.0%; The drug resistance to ertapenem, imipenem, cefoperazone/sulbactam, piperacillin/tazobactam and other antimicrobial were less than 2.0%. the resistance rate to cefoxitin, amikacin, amoxicillin/clavulanic acid was between 1.5% and 8.5%。Conclusion:Hospital patients with surgical excision of wound secretions of Escherichia coli accounted for the largest proportion.; The clinical empirical use of antimicrobial drugs should be based on the above mentioned sensitive drugs and the drug sensitivity test results ; Rational use of antibiotics to reduce the generation of resistant strains. |
