| ABSTRACT Objective:To analyze the results of therapeutic drug monitoring(TDM) from 2013 to 2015 in our hospital were analyzed, so as to provide rational clinical use of drug. Methods:Retrospective analysis method was used, the TDM of serum concentrations of valproate sodium, carbamazepine and phenobarbital used in 1 098 cases were collected, statistical analysis was conducted. Results:Among the 1 098 cases,the numbers of patients used valproate sodium,carbamazepine and phenobarbital were 1 009, 65 and 24, each ratio of concentration in recommended range was 42.6%, 64.6%, 37.6%, respectively. The total of the combination drug use was 31 cases, 8 patients with effective concentration of all drugs (25.8%). The time of last last administration and blood sampling had great influence on the results of TDM. Conclusion:The effective concentration of anti epilepsy drugs varied in different patients and many factors were included. Clinicians should consider the use of drugs comprehensively, and make personalized medicine scheme to improve rational drug use and safety． |
