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| 188例冠心病患者造影剂使用前后肾功能检查及危险因素分析 |
| Renal Function Examination Before and After Coronary Angiography in 188 Patients with Coronary Artery Disease and Analysis of Risk Factors |
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| DOI： |
| 中文关键词: 造影剂 肾功能 造影剂肾病 危险因素 |
| 英文关键词:Contrast media Renal function Contrast induced nephrology Risk factors |
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| 中文摘要: |
| 摘 要 目的：了解冠心病患者行冠状动脉造影术前后肾功能检查和造影剂使用情况。方法：回顾性调查行冠状动脉造影术冠心病患者的基础疾病、造影剂类型及用量、肾功能检查情况、合并用药等情况，对比发生造影剂肾病（CIN）及未发生CIN患者的临床特点，并对相关危险因素进行分析。结果：共调查行冠状动脉造影术的冠心病患者188例，男132例（70.2%），女56例（29.8%）；平均年龄（60.41±9.68）岁，大于75岁的病例有18例（9.6%）。合并基础疾病最多是高血压、心功能不全、糖尿病；使用造影剂主要是碘海醇，平均用量（139.98±81.82）ml。所有患者术前均检查肾功能，术后复查肾功能者54例（28.7%），其中3例发生CIN。CIN患者糖尿病病例数、造影剂用量与未发生CIN患者相比差异有统计学意义（P<0.05）；CIN患者的内生肌酐清除率也低于正常组，但差异无统计学意义（P＞0.05）。未复查肾功能患者部分存在发生CIN的一种或多种危险因素。结论：冠心病患者多存在至少一种发生CIN的危险因素，行冠状动脉造影术应提高警惕，造影术后复查肾功能的意识有待加强。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the renal function examination result before and after coronary angiography and the use of contrast media in patients with coronary artery disease. Methods:Retrospective study was used to analyze the underlying diseases，contrastagents，renal function examination，combined medication of patients with coronary artery disease. The clinical features of the contrast induced nephropathy(CIN) and normal group were compared and analyzed. Results: In 188 cases，the mean age was （60.41±9.68） years，132 males（70.2%）and 56 female（29.8%），18 cases were more than75 years old(9.6%). Most cases were complicated with hypertension，heart failure and diabetes mellitus；iohexolwas used most widely，in a dose of (139.98±81.82) ml. All cases renal function were examined preoperative but 54cases (28.7%) were examined postoperative only，3 cases were diagnosed as CIN. The difference was statistically significant (P< 0.05) in the number of diabetic patients, contrast media dosage of CIN. The endogenous creatinine clearance rate were also lower than the normal group, but the differences were not statistically significant (P> 0.05). One or more risk factors of CIN in those renal function were not examined postoperative.Conclusion:Most of the patients with coronary heart disease had at least one risk factor lead to CIN ，the concept of reexamine renal function after percutaneous coronary intervention needed to be strengthened. |
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