| ABSTRACT Objective:To make a Meta-analysis on the efficacy and safety of felodipine vs. nifedipine for the treatment of Chinese patients with essential hypertension by Meta-analysis. Methods: The Cochrane Library (Issue11,Nov.2016), PubMed, MEDLINE, Embase, CNKI, WanFang Data, VIP, SinoMed were electronically searched up to 15st November 2016. Randomized controlled trials (RCTs) that reported felodipine vs. nifedipine in treating Chinese patients with essential hypertension were included. Meta-analysis was performed by RevMan 5.3 statistical software on the basis of critically evaluated the quality of the included studies with the Cochrane systematic evaluated manual. The evidence quality was assessed with GRADE profiler 3.6 software. Results:14 RCTs with 1 909 patients were included. Meta-analysis indicated that the total effective rate in patients receiving felodipine was significantly higher than that in patients receiving nifedipine (OR=3.58, 95%CI: 2.08 6.18, P＜0.05), and the excellent rate (OR=2.24, 95%CI: 1.52 3.31, P＜0.05), and ΔSBP (MD=5.83, 95%CI: 0.70 10.97,P＜0.05), and ΔDBP (MD=3.63, 95%CI:-0.02 7.29,P=0.05). While the adverse drug reaction(ADR) rate was significantly lower in the felodipine group compared to the nifedipine group (RR=0.41, 95%CI: 0.31 0.55, P＜0.05). The evidence quality was very low in total effective rate, ΔSBP and ΔDBP; low in excellent rate and ADR rate. And the strength of recommendation was 2. Conclusion:The result indicated that felodipine was better than nifedipine on efficacy and safety, which is thus worthy of clinical application. Due to the poor quality of included studies, high quality RCT were required to further validate above conclusions. |
