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| 斑蝥酸钠维生素B6 联合顺铂及白介素-2 胸腔内热灌注治疗肺癌恶性胸腔积液观察 |
| Observation of Sodium Cantharidinate and Vitamin B6 Combined with Cisplatin and IL-2 Intrathoracic Hyperthermic Perfusion in Treatment of Malignant Pleural Effusion of Lung Cancer |
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| DOI： |
| 中文关键词: 斑蝥酸钠维生素B6 顺铂 白介素-2 热灌注 肺癌 恶性胸腔积液 |
| 英文关键词:Cantharidin sodium vitamin B6 Cisplatin Iterleukin-2 Hyperthermic perfusion Lung cancer Malignant pleural effusion |
| 基金项目:湖北省卫生厅科研基金一般项目（编号：JX5B03） |
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| 中文摘要: |
| 摘 要 目的：探讨斑蝥酸钠维生素B6 联合顺铂和白介素 2（IL 2）胸腔内热灌注治疗肺癌恶性胸腔积液的疗效和安全性。方法：70例确诊肺癌并首次出现胸腔积液的患者随机分为试验组和对照组各35 例，均行胸腔置中心静脉管闭式引流，排尽胸腔积液。此后试验组胸腔内热灌注斑蝥酸钠维生素B6 注射液、顺铂及IL-2；对照组胸腔内普通灌注顺铂及IL-2。两组均每周治疗1次，共治疗4周。比较两组患者的疗效、生活质量（KPS评分）、药品不良反应和胸腔积液复发情况。 结果：试验组有效率为82.5%，显著高于对照组（P＜0.01) 。两组患者治疗后KPS评分均较前显著提高（P＜0.05)， 但组间差异无统计学意义(P＞0.05)。两组药品不良反应差异无统计学意义(P＞0.05) 。试验组患者胸腔积液近期复发率降低，且复发时间显著推迟（P＜0.05)。结论：与传统胸腔灌注化疗比较，斑蝥酸钠维生素B6 注射液、顺铂及IL-2联合经胸腔热灌注治疗肺癌恶性胸腔积液疗效较好，能改善患者生存质量，不良反应无明显增加，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the efficacy and adverse reaction of intrathoracic hyperthermic perfusion with sodium cantharidinate vitamin B6 , cisplatin (DDP) and interleukin 2 in the treatment of lung cancer with malignant pleural effusion. Methods: 70 cases diagnosed as lung cancer with pleural effusion were randomly divided into the experimental group (n=35) and control group (n=35). All of them were performed closed drainage of pleural effusion with central venous puncture tube. Then, cisplatin and interleukin-2 were perfused into pleural cavity in control group. While, in the experimental, cantharis acid sodium, vitamin B6 , cisplatin and interleukin-2 were used with thermal perfusion. Finally，therapy effect，quality of life，adverse drug reactions and relapse were compared between the two groups. Results:The effective rate of therapy in experimental group (82.5%) was obviously higher than the control one(55%，P<0.01). The evaluation on quality of life (KPS) showed all the patients lived better than pre therapy（P＜0.05), but no distinction between groups(P＞0.05). Similarly, there was no significant difference in adverse drug reactions between the two groups (P＞0.05). Moreover，the recurrence rate of pleural effusion in the experimental group was decreased obviously and the recurrence time was significantly delayed（P＜0.05). Conclusion:Cantharidin sodium, vitamin B6 , cisplatin and interleukin-2 combined with hyperthermic pleural perfusion to therapy for malignant pleural effusion showed more effective and safe which can improve the quality of life of patients. It is an effective method for treatment of lung cancer with malignant pleural effusion which is worth promoting in the clinical. |
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