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| 2014～2016 年西京医院256例中药不良反应报告分析 |
| Adverse Drug Reactions Induced by Chinese Patent Medicine in Xijing Hospital During 2014 2016: Analysis of 256 Cases |
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| DOI： |
| 中文关键词: 中成药 药品不良反应 报告 药物警戒 |
| 英文关键词:Chinese patent medicine Adverse drug reaction Report Pharmacovigilance |
| 基金项目:国家自然科学基金项目(编号：81573549) |
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| 中文摘要: |
| 摘 要 目的：分析西京医院2014年1月～ 2016年6月中成药不良反应（ADR）报告的特点与规律，为加强中成药的ADR监测提供参考。方法：按照患者的性别与年龄、给药途径、剂型、引发ADR的主要药品、累及器官或系统、ADR的类型等项目，对256例中成药ADR报告进行统计分析。结果：256例中成药ADR报告中，女性占59.37％；涉及30种中成药，其中报告3例次及以上的有30种，占总例次的100％；口服用药引起的ADR最多，占72.6％，其次是静脉给药，占25.8％；ADR的临床表现以消化系统最多，占33.5％，其次是感觉器损害占23.8％。结论：中成药的ADR与多种因素有关，应做好监测以促进其用药安全。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the characteristic and regularities of the adverse drug reactions（ADR）induced by Chinese patent medicine in Xiamen city during Jan.2014 to June 2016 for reference of strengthening monitoring on the ADR of Chinese patent medicine.Methods:A total of 256 ADR cases induced by Chinese patent medicine were analyzed statistically with regard to age and gender,route of administration，dosage forms，major ADR inducing drugs，organs or systems involved，and ADR types. Results:of the 256 ADR cases，women accounted for 59.37％；a total of 30 Chinese patent drugs were involved，with 30espectively induced ADR of at least 3 cases，and the total ADR cases induced by the 30 drugs represented 100％ of the total ADR cases；72.6％ of the ADR cases were induced by oral drugs followed by intravenous drug（25.8％）. 35.5％ of the ADR cases manifested as lesion of digestive system and 23.8％ by sensory organs lesions. Conclusion:The ADRs of Chinese patent medicine were associated with multiple factors thus their ADR monitoring should be emphasized to promote medication safety of Chinese patent medicine. |
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