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| 基于本体的国内抗感染药物不良反应报告分析 |
| Ontology based Analysis of Adverse Drug Reactions Reports Associated with Domestic Anti infection Drugs |
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| DOI： |
| 中文关键词: 抗感染药物 药品不良反应 不良事件本体 |
| 英文关键词:Anti infection drugs Adverse drug reactions Ontology of adverse events |
| 基金项目:吉林省教育厅“十二五”社会科学研究项目（编号：吉教科文合字[2014]第B020号）；吉林大学研究生创新基金资助项目（编号：2016110） |
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| 中文摘要: |
| 摘 要 目的：了解国内抗感染药物不良反应（adverse drug reactions, ADR）的发生情况。方法：通过国家人口与健康科学数据共享平台的2 355 例ADR报告，基于不良事件本体（ontology of adverse events, OAE），利用文本处理语言perl编程进行数据处理，分析ADR报告中患者的性别年龄分布、给药途径、药物种类与构成比、发生最多的不良反应、严重不良反应信息。结果：在所有病例报告中，男女例数相当，30～40 岁的例数最多，占18.76%，中药引起10 岁以下患儿ADR例数最多，占23.81%，引起ADR最多的给药途径是静脉滴注，药物类别是喹诺酮类，最常见的ADR症状是胸闷。结论：基于本体的方法可以有效地分析不良反应。另外，应对抗感染药物ADR引起足够重视，加强抗感染药物ADR监测，促进抗感染药物合理应用。 |
| 英文摘要: |
| ABSTRACT Objective:To analyze the adverse drug reactions (ADRs) of domestic anti infection drugs.Methods:2 355 case reports were obtained from the national scientific data sharing platform for population and health. Based on the ontology of adverse events (OAE), we utilized the text processing language perl to process the data. The patients’ age and gender distribution, the administration routes, the drug classes and constituent ratios, the most ADRs, the severe ADRs were analyzed through statistical analysis methods.Results: In all case reports, ADRs of anti infections in males and females were basically similar. Most reports of ADRs were found among the patients aged 30 to 40 and accounted for 18.76%. The most reports involving traditional Chinese drugs were for children under 10 years of age and account for 23.81%. Administration routes that caused the most ADRs was intravenous drip. The drug category that caused the most ADRs was quinolone class. And the chest discomfort was the primary ADR in these reports.Conclusion:We could analyze the ADRs effectively based on the ontology. Furthermore, we should pay attention to the ADRs of anti infections and strengthen the ADR monitoring of anti infection drugs to promote the reasonable application of anti infections. |
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