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| 基于Meta分析的灯盏花素注射剂治疗急性脑梗死临床评价研究 |
| Meta analysis of Breviscapine Injection in the Treatment of Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 灯盏花素注射剂 急性脑梗死 随机对照试验 Meta分析 |
| 英文关键词:Breviscapine injection Acute cerebral infarction Randomized controlled trials Meta analysis |
| 基金项目:国家自然科学基金项目（编号：81473547；编号：81673829） |
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| 中文摘要: |
| 摘 要 目的：系统评价灯盏花素注射剂联合西医常规治疗急性脑梗死（ACI）的临床疗效及安全性。方法：系统检索Embase、PubMed、the Cochrane Library、中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（VIP）、中国生物医学文献数据库（SinoMed）、万方数据库1979~2016年的文献，全面搜集灯盏花素注射剂联合西医常规治疗ACI的随机对照试验，对纳入文献进行质量评价，提取资料并通过RevMan 5.3 软件进行数据分析。结果：共纳入20篇文献，累计2 459例受试者。Meta分析结果显示：在常规用药的基础上，联合使用灯盏花素注射剂，临床总有效率显著提高（RR＝1.28, 95%CI：1.17~1.39,P<0.000 01）。此外，灯盏花素注射剂还可降低血液流变学指标，且未见严重的不良反应发生。结论：在西医常规治疗的基础上联合使用灯盏花素注射剂对ACI有较好的疗效，但其安全性仍需进一步探讨。 |
| 英文摘要: |
| ABSTRACT Objective:To systematically evaluate the clinical effectiveness and safety of breviscapine injection combined with conventional therapy in the treatment of acute cerebral infarction (ACI). Methods:According to literature databases, a thorough and systematic retrieval of randomized controlled trials (RCTs) which regarding breviscapine injection for treating ACI was conducted. The Cochrane Risk of Bias Assessment Table was used to evaluate the methodological quality of the RCTs and then the data were extracted and Meta analysed by RevMan5.3 software. Results: A total of 20 RCTs with 2 459 participants were included. In the Meta analysis, the combining use of breviscapine injection and conventional therapy in the treatment of ACI can achieve a higher total effective rate (RR=1.28, 95%CI: 1.17-1.39, P<0.000 01). Furthermore, breviscapine injection can improve hemorheologic parameters. And there was no major or serious adverse drug event. Conclusion:Breviscapine injection combined with conventional therapy has good therapeutic effect on ACI. |
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