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| 基于Meta分析的脉络宁注射液治疗冠心病心绞痛临床评价研究 |
| Meta analysis of Mailuoning Injection in Treatment of Angina Pectoris |
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| DOI： |
| 中文关键词: 脉络宁注射液 冠心病心绞痛 Meta分析 随机对照试验 |
| 英文关键词:Mailuoning injection Angina pectoris Meta analysis Randomized controlled trials |
| 基金项目:国家自然科学基金项目（编号：81473547、81673829） |
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| 中文摘要: |
| 摘 要 目的：系统评价脉络宁注射液治疗冠心病心绞痛的临床疗效及安全性。方法：计算机检索中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（VIP）、万方数据库、中国生物医学文献数据库（SinoMed）、PubMed、Embase和the Cochrane Library数据库，全面检索脉络宁注射液治疗冠心病心绞痛的随机对照试验，采用Cochrane风险评价表评价其研究质量，提取资料并通过RevMan 5.3软件进行数据分析。结果：共纳入7篇文献，累计587例受试者。Meta分析结果显示：对比仅用西医常规，或西医常规联用其他中药制剂的对照组，西医常规治疗的基础上联用脉络宁注射液在治疗冠心病心绞痛方面可提高临床总有效率（RR=1.25, 95% CI: 1.16~1.36, P<0.000 01），提高心电图总有效率（RR=1.37, 95%CI: 1.16~1.61, P=0.000 2）；同时，可以降低血小板聚集率等。结论：临床治疗冠心病心绞痛的过程中，在常规治疗的基础上加用脉络宁注射液可以提高疗效，但其安全性仍需进一步探讨，且需更多随机双盲对照试验加以验证。 |
| 英文摘要: |
| ABSTRACT Objective:To systematically evaluate the clinical effectiveness and safety of Mailuoning injection in treatment of angina pectoris. Methods:Randomized controlled trials regarding angina pectoris treated by Mailuoning injection were searched in the China National Knowledge Infrastructure Database, China Scienceand Technology Journal Database, Wanfang Database, Chinese Biomedical Literature Database, the Cochrane Library, Embase and PubMed. The publishing time was no later than February 2016. Quality of included RCTs was evaluated by The Cochrane Risk of Bias Assessment Tool, and then the required information was extracted and Meta analyzed by RevMan 5.3 software. Results: A total of 7 RCTs with 587 participants were included. In the Meta analysis, Mailuoning injection combined with conventional medicine can achieve a better effect than those in conventional medicine alone in respect of total effective rate (RR=1.25, 95% CI:1.16-1.36, P<0.000 01), the total effective rate of ECG (RR=1.37, 95% CI: 1.16 1.61, P=0. 000 2). In addition, Mailuoning injection could decrease platelet aggregation rate.Conclusion: Mailuoning injection combined with conventional medicine was effective in treating Angina Pectoris, while its safety still needed to be further investigated，the evidence required large scale and double blind RCTs to substantiate these findings. |
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