| ABSTRACT Objective:To analyze adverse drug reactions(ADRs) occurred in elderly patients in order to study the characteristics of the elderly ADRs.Methods:A total of 5 411 elderly ADRs reports were included in 2015 in the database of PLA ADR monitoring center. The patients’ age, gender, number of suspected drug, the first suspected drug types, the involved system/damaged organ, ADRs behavior, ADRs induction period, the relevance evaluated and outcome, reported type and occupation distributiion were analyzed statistically. Results: Among 5 411 elderly ADRs reports, ratio of males and females was 1.28:1. multiple suspected drug exposure experienced a high proportion of serious ADRs compared with the single suspected drug use（P＜0.001）. Many systems/organs (6 104 frequencies) were involved in 5 411 ADRs reports, in which the most common is the gastrointestinal disorders (1 276 frequencies,20.90%),followed by the skin and appendages disorders (1 110 frequencies,18.18%) and body as a whole general disorders (877 frequencies,14.37%).Nausea(753 frequencies,9.88%) and rash (694 frequencies, 9.10%) were the commonest symptoms. 57.72% ADR occurred within 6 hours after administration.Conclusion:The elderly ADRs reports involved various drug categories and multiple systems/ organs. In order to recognize and prevent ADRs in time, It was important to strengthen ADRs monitoring and assess medication risks in elderly patients to ensure their medication safety. |
