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| 基于Meta分析的复方丹参注射液治疗急性脑梗死临床评价研究 |
| Meta analysis on Randomized Controlled Trials of Compound Danshen Injection in Treatment for Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 复方丹参注射液 急性脑梗死 Meta 分析 |
| 英文关键词:Compound danshen injection Acute cerebral infarction Meta analysis |
| 基金项目:国家自然科学基金课题（编号：81473547、81673829） |
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| 中文摘要: |
| 摘 要 目的：采用Meta分析方法评价复方丹参注射液辅助西医常规治疗急性脑梗死的有效性、安全性。方法：计算机检索the Cochrane Library、PubMed、Embase、SinoMed、中国知网、维普期刊数据库和万方数据库有关复方丹参注射液治疗急性脑梗死的随机对照临床试验文献，检索时限为各数据库建库至2016年9月。采用Cochrane风险评价表评价其研究质量，提取资料通过Stata 13.1进行Meta分析。结果：共纳入10个随机对照试验，累计948名患者。Meta分析结果显示，复方丹参注射液辅助西医常规可提高临床疗效总有效率（RR=1.24，95%CI：1.14~1.35，P＜0.01），改善神经功能缺损（MD=-4.78, 95%CI：-7.27~-2.30，P<0.01），提高患者日常生活活动能力。有2篇文献明确无不良反应，1篇研究报道了共1例不良反应，其他文献均未对安全性进行说明。结论：当前证据表明复方丹参注射液辅助西医常规治疗在提高临床疗效总有效率、改善神经功能缺损、提高患者日常生活活动能力方面优于单一的西医常规治疗，对于安全性,尚需要更多高质量的研究予以证实。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate systematically the clinical effectiveness and safety of compound dansen injection (CFDS) on acute cerebral infarction (ACI). Methods: Randomized controlled trials regarding ACI treated by CFDS and routine western medicine were searched in the China National Knowledge Infrastructure Database, China Scienceand Technology Journal Database, Wanfang Database, Chinese Biomedical Literature Database, PubMed, Embase and Cochrane Library up to Sep, 2016. Two reviewers independently retrieved RCTs and extracted information. The Cochrane risk of bias method was used to assess the quality of included studies, and a Meta analysis was conducted with Stata 13.1 software.Results:10 studies involving 948 participants were included. Meta analysis, the results of CFDS group was significantly superior to the routine western medicine group in the total effective rates (RR=1.24, 95%CI: 1.14 1.35, P＜0.01), the neurologic impairment (MD=-4.78, 95%CI: -7.27 -2.30, P<0.01), the activities of daily living. 2 articles cleared that there was no ADRs in the studies, 1 study reported 1 case of ADR. Conclusion:Comparing with routine western medicine, the combine use of CFDS was more effective in improving the total effective, the neurologic impairment and the activities of daily living，However, safety still needed for further studies. |
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