| ABSTRACT Objective:To systematically evaluate the clinical effectiveness and safety of Aidi injection combined with FOLFOX chemotherapy regimen in the treatment of colorectal cancer. Methods:Eligible studies were searched in PubMed, the Cochrane library, Embase, CNKI, SinoMed, VIP, and Wanfang databases from establishment to October 2016. Two researchers independently identified RCTs of Aidi injection treating for colorectal cancer. The methodological quality of the included RCTs was evaluated, and then the data were extracted and Meta analyzed by RevMan5.3 software. Results:12 RCTs involving 932 patients were included. In the Meta analysis, Aidi injection combined with FOLFOX chemotherapy regimen can be better than FOLFOX chemotherapy regimen alone in the treatment of colorectal cancer in respect of improvement in life quality (RR=2.05, 95%CI:1.69-2.49, P<0.000 01). In addition, Aidi injection can reduce the adverse reactions, and improve immunologic function. However, the total effective rate was also improved in colorectal cancer patients with Aidi injection combined with FOLFOX chemotherapy regimen (RR=1.16, 95%CI: 1.00-1.35,P=0.05). Conclusion:Thus, our study showed that Aidi injection combined with FOLFOX chemotherapy regimen is beneficial in the treatment of colorectal cancer, while our conclusion should be confirmed by more well designed and large scale randomized controlled trials. |
