| ABSTRACT Objective:To evaluate systematically the effectiveness and safety of Danhong injection (DH) versus compound salvia miltiorrhizae injection (CSM) in treating patients with acute cerebral infarction (ACI). Methods: Randomized controlled trials regarding ACI treated by DH and CSM were searched in the China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database, Chinese Biomedical Literature Database, PubMed and the Cochrane Library up to October, 2016. Two reviewers independently retrieved RCTs and extracted information. The Cochrane risk of bias method was used to assess the quality of included studies, and Meta analysis was conducted with Stata 13.1 software. Results:18 studies involving 1 986 participants were included. The results of Meta analysis showed DH group was significantly superior to CSM group in the total effective rates(RR=1.22, 95%CI:1.17-1.27, P<0.01), the neurologic impairment (MD=-3.75, 95%CI：-5.03 -2.46, P<0.01). There was no obvious difference in reducing mortality. Additionally, DH also can improve the level of hemodynamic indices. 7 articles cleared that there was no ADRs in the studies, 2 studies reported 7 ADRs. Conclusion: Current evidence suggested that DH injection combined with conventional therapy was superior to compound salvia miltiorrhizae injection for acute cerebral infarction. However, safety still needed to be verified further by more large scale and well designed RCTs. |
