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| 唑来膦酸联合放疗治疗恶性肿瘤骨转移性疼痛疗效观察 |
| Observation of Curative Effect of Zoledronic Acid Combined with Radiotherapy in Treatment of Malignant Tumor Bone Metastases |
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| DOI： |
| 中文关键词: 恶性肿瘤 骨转移性疼痛 唑来膦酸 放疗 |
| 英文关键词:Cancer Metastatic bone pain Zoledronic acid Radiation therapy |
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| 中文摘要: |
| 摘 要 目的：观察唑来膦酸联合放疗治疗恶性肿瘤骨转移性疼痛中的效果。方法：恶性肿瘤骨转移性疼痛患者88例随机分为观察组与对照组各44例。两组患者均接受放疗，在此基础上观察组加用唑来膦酸。连续治疗3~4个月后，比较两组患者疼痛和活动能力改善情况，评价两组疼痛VAS评分和生活质量Karnofsky评分变化。结果：观察组的疼痛缓解率和活动能力改善率均显著高于对照组（P<0.05）。治疗后，两组VAS评分显著降低，Karnofsky评分显著提高（P<0.05）；且观察组两项评分均明显优于对照组（P<0.05）。两组药品不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：唑来膦酸联合放疗治疗恶性肿瘤骨转移性疼痛，能够有效缓解患者的疼痛，改善患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective:To observe the effect of zoledronic acid combined with radiotherapy in the treatment of malignant tumor of bone metastatic pain. Methods:patients with malignant tumor of bone metastatic pain were randomly divided into observation group and control group(n=44). Two groups of patients were underwent radiotherapy, on the basis of the observation group added with zoledronic acid. 3-4 weeks were considered 1 course of treatment, continuous treated 3-4 months. Two groups of patients' pain and improvment activity were compared, pain VAS score and quality of life Karnofsky score changes of two groups were evaluated. Results:The pain relief rate and the activity period of observation group were significantly higher than that of control group(P<0.05). After the treatment, the VAS score decreased significantly and Karnofsky score increased significantly in both groups(P<0.05); Two scores above of observation group were significantly better than that of control group(P<0.05).Compared the incidence of adverse drug reactions of two groups, there was no statistically significant difference(P>0.05). Conclusion:Zoledronic acid combined with radiotherapy in treatment of malignant tumor bone metastases pain, could effectively reduce the pain of patients, improve the patient's quality of life. |
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